Abstract
In order to find out an appropriate therapeutic dose of bucumolol, a newly developped β-blocker, the effects of 30mg/day and 60mg/day of the drug on angina pectoris and arrhythmias were studied by means of double blind group comparison method.Of 66 patients with angina, general improvement rating was better in 28cases of 30mg/day group than in 38cases of 60mg/day group (P=0.085), while no signifi-cant difference in usefulness was observed between two groups.The rates of decrease of the anginal attacks and nitroglycerin consumption were higher in the former group (P=0.053 and P=0.024).Of 46 patients with premature beats, general improvement rating and usefulness were significantly better in 24 cases of 30 mg/day group (P=0.025 and P=0.027), but no significant difference was seen in the rate of decrease of premature beats between two groups.The incidence of side effects was 18 among 132 cases (13.6%).These data indicate that 30 mg/day of bucumolol is recommended for the treatment of angina and arrhythmias.
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Schedule a callMore From: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
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