Aerobic exercise combined with trimetazidine can improve the left ventricle′s systolic function in angina patients

Abstract

Objective To observe the impact of aerobic exercise combined with trimetazidine (TMZ) on the left ventricle′s systolic function among stable angina patients. Methods Seventy-three stable angina patients treated in the Cardiology Department of the Fourth Hospital of Hebei Medical University between June 2015 and June 2016, were selected and randomly divided into an observation group, a medicine group and a control group. All three groups were given routine drug therapy, while the medicine group and observation group were additionally provided with TMZ, and TMZ combined with aerobic exercise respectively for 3 months. Nitroglycerin consumption, angina attacks and left ventricular systolic function were recorded before and after the treatment. Results Before the treatment there were no significant differences in average nitroglycerin consumption, the frequency of angina attacks or left ventricular systolic function among the three groups. After the 3 months of treatment, left ventricular systolic function in theobservation group had improved significantly on average compared with before treatment and with the other two groups after the treatment. Nitroglycerin consumption and angina attacks were significantly less as well. Conclusion Aerobic exercise combined with TMZ can significantly improve the left ventricular function of stable angina patients, which is of great significance for alleviating their condition and reducing the incidence of cardiovascular disease. Key words: Aerobic exercise; Trimetazidine; Angina; Coronary artery disease; Left ventricle; Systolic function