Abstract
Dopexamine is a dopamine analog that has been used for hemodynamic optimization in a number of clinical settings. This animal investigation showed anti-inflammatory effects of dopexamine in a rat endotoxin model without effects on global or regional flow, but it is not time to dispense with hemodynamics altogether just yet. Rather, an integrative approach to the effects of catecholamines, considering both inflammatory and hemodynamic effects, including those on the microcirculation, can help clinicians best understand how to employ them in clinical practice.
Highlights
Busy clinicians sometimes think twice before reading studies of animal models
Dopexamine may be different Use of dopexamine targeted to increase oxygen delivery to >600 ml/minute/m2, was shown in a randomized trial reported in 1993 to decrease mortality in the perioperative period [7]. Whether this resulted from differential hemodynamic effects of dopexamine compared with other agents, perhaps selective vasodilation of regional circulations, or whether use of inotropes for perioperative optimization is different from their use in other settings was not entirely settled
Inflammation or hemodynamics? The current study investigated both hemodynamic and inflammatory effects of a low dose of dobutamine in a rodent model of endotoxemia
Summary
Busy clinicians sometimes think twice before reading studies of animal models. Yes, it sounds interesting, but is it really going to change my practice? There is so much else I should be reading. Introduction Busy clinicians sometimes think twice before reading studies of animal models. Animal studies are most useful when they illuminate clinical issues.
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