Abstract
The specific binding of 3H-labelled haloperidol (3H-Hal) and the basal and dopamine-stimulated adenylate-cyclase activity in vitro were investigated in mice treated with a single dose or with repeated doses of neuroleptic drugs. These dose regimens are known to induce behavioural supersensitivity and to decrease dopamine synthesis and release a few days after cessation of dosage.
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