Abstract
1. 1. The binding of 3H-haloperidol ( 3HHal) and 3H-cis(Z)-flupenthixol ( 3H-FPT) and the dopamine stimulated adenylate cyclase (AC) activity in striatal tissue were investigated in vitro. 2. 2. 3HHal and 3H-FPT bind to striatal membranes in a saturable manner with dissociation constants of 3.1 and 3.8 nM, respectively. The number of binding sites for 3H-FPT was 3 times larger than for 3H-Hal. 3. 3. The binding of the two ligands seems to be related to dopamine receptors. 4. 4. Neuroleptics inhibited binding of 3H-Hal and 3H-FPT and dopamine stimulated AC activity. Butyrophenones and diphenylbutylpiperidines were weak inhibitors of both 3H-FPT binding and AC activity. 5. 5. A very close correlation between the effects in 3H-FPT binding and AC was found whereas the correlations 3H-Hal versus 3H-FPT and 3H-Hal versus AC were much weaker.
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