Abstract
In the present study, the involvement of dopamine D 1 and D 2 receptors in the dorsal globus pallidus (GP) in motor control was investigated in rats. Results show that bilateral microinfusions of the dopamine D 1 receptor antagonist SCH23390 or the dopamine D 2 antagonist S(−)-sulpiride into the GP induced akinesia determined by means of the catalepsy test. These findings indicate that pallidal dopamine D 1 and D 2 receptors are critically involved in the control of motor behaviour. The findings further imply that defective dopaminergic transmission in the GP might contribute to akinesia due to lesion- or drug-induced dopamine hypofunction in experimental animals and in neurodegenerative diseases, e.g. Parkinson’s disease, affecting the nigrostriatal dopamine system.
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