Abstract
The spatial organization of phospholipids and sterols in cellular membranes is believed to play an important role in membrane function and cell activities. Both recent experimental and simulation studies have suggested various possible heterogeneous spatial distributions of lipids and cholesterol, including the formation of nanoscale lipid domains, in multi-component bilayer systems. In this study, we use coarse-grained Molecular Dynamics simulations to study the phase behavior of quarternary lipid mixtures as a function of membrane composition. We focus on the formation and size of nanoscopic lipid domains, their compositions, and their signatures in observables such as partial density correlation functions and structure factors.
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