Abstract
ABSTRACTDogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.
Highlights
Domestic dogs (Canis lupus familiaris) are the most variable mammalian species on Earth [1,2,3] (Fig. 1)
Dog10K will expand that applicability by developing an exhaustive catalog of genetic variation to enable the generation of an accurate imputation panel for dog genome-wide association studies (GWAS), in much the same way that the 1000 Genomes Project has improved the study of low-frequency variants in human association studies
Will dense sequencing of key breeds enhance the ability to find susceptibility loci, genes and variants, but the ensuing results are more likely to mimic those of humans than those observed in more common model systems such as mice, where disease states are often induced rather than naturally occurring
Summary
Domestic dogs (Canis lupus familiaris) are the most variable mammalian species on Earth [1,2,3] (Fig. 1). Wholegenome sequencing (WGS) studies of numerous populations, breeds and wild canids are crucial to advance our basic knowledge regarding the genetic outcomes of canine evolution (Fig. 2). Generating genome sequences on this scale will enable us to identify and characterize signals of selection related to domestication and dog breed formation at an unprecedented level of detail.
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