Abstract
A Dog's Eye View of Morphological Diversity
Highlights
The history of genetic discovery offers a lesson in inspired choices
Mendel pried the principles of inheritance from the seeds, pods, and flowers of pea plants
McClintock showed that genes could change position on a chromosome by charting the idiosyncrasies of every leaf and kernel of her beloved maize plants
Summary
The history of genetic discovery offers a lesson in inspired choices. Mendel pried the principles of inheritance from the seeds, pods, and flowers of pea plants. Working with longtime collaborators Carlos Bustamante and Robert Wayne, Ostrander and her colleagues report that complex traits like body size and coat color may fall under the control of surprisingly few genes. Pure-bred dogs, with their storied history of intensive breeding for humans’ prodigious preferences, offer geneticists a unique opportunity to link variations at a given spot in the genome (the genotype) with the physical expression (phenotype) of complex traits.
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