DOG1, alpha-amylase and p63 expression in acinic cell carcinoma of salivary gland; immunohistochemical, clinical and radiological study

Ihab Shafek Atta,Fahd Nasser Al Qahtani

doi:10.7243/2055-091x-2-13

Abstract

Abstract Introduction: Identification of serous acinar differentiation is the basic step for the diagnosis of acinic cell carcinoma (ACC). α-amylase was described to be specific for normal acinar cell but its

Highlights

Identification of serous acinar differentiation is the basic step for the diagnosis of acinic cell carcinoma (ACC). α-amylase was described to be specific for normal acinar cell but its affinity to malignant counterpart is being contentious
Significant correlation was obtained between results of DOG1 and α-amylase with p-value=0.034, significant correlation was obtained between DOG1 and p63 with p-value=0.02
Significant correlation was obtained between results of DOG1 and α-amylase with p-value=0.034, significant correlation was obtained between DOG1 and p63 with p-value=0.02, on the other hand, no significant correlation was obtained between results of both α-amylase and p63 with p-value= 0.546 (Table 1)

Summary

Introduction

Identification of serous acinar differentiation is the basic step for the diagnosis of acinic cell carcinoma (ACC). α-amylase was described to be specific for normal acinar cell but its affinity to malignant counterpart is being contentious. Identification of serous acinar differentiation is the basic step for the diagnosis of acinic cell carcinoma (ACC). Α-amylase was described to be specific for normal acinar cell but its affinity to malignant counterpart is being contentious. Discovered marker anoctamin (DOG1) specific for diagnosis of GISTs has been reported for its efficacy to stain the malignant acinar cells and so, it is being of value in ACC diagnosis. Acinic cell carcinoma (ACC) is a low grade malignant tumor and represents about 17% of all salivary tumors. Variable microscopic variants and patterns are seen as solid, papillary, cystic, microcystic, follicular and lymphoid. In addition to these variants, cells in ACC may be granular, clear or vacuolated. Irrespective of cell type, scant mitoses are generally seen [4,5]

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Discussion

Conclusion