Abstract
The relationship between leishmaniasis and COVID-19 remains uncertain, with no evidence suggesting that leishmaniasis provides protection against COVID-19. Leishmaniasis, transmitted by sandflies, and COVID-19, caused by the SARS-CoV-2 virus, are unrelated diseases with distinct transmission modes. It is essential to rely on established preventive measures for COVID-19, such as vaccination and hygiene practices, as leishmaniasis requires separate medical attention. Some studies suggest that visceral Leishmania-COVID-19 co-infection may reactivate asymptomatic leishmaniasis. Severe COVID-19 cases may exacerbate parasitic multiplication and organ involvement. The immunological response to visceral leishmaniasis may increase susceptibility to subsequent SARS-CoV-2 infection, emphasizing the importance of an effective immune response. Cutaneous leishmaniasis may confer cross-protection against COVID-19, particularly in tropical regions. IFN-γ plays a critical role in parasite control and antiviral defense, highlighting its importance in both diseases. Further research is needed to understand the mechanisms underlying the interaction between SARS-CoV-2 and leishmaniasis.
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