Does Sciaena umbra (Linnaeus 1758) otolith protect tissues against nephropathy, oxidative stress and inflammation induced by ethylene glycol?

Laçine Aksoy,Mesturi̇ye Yaylali,Mukhri̇ddi̇n Suyundikov

doi:10.1590/0001-3765202020191279

Laçine Aksoy, Mesturi̇ye Yaylali + Show 1 more

Open Access

https://doi.org/10.1590/0001-3765202020191279

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Abstract

Sciaena umbra is a species of fish with large otoliths. These otoliths are used for treatment of kidney stone disease with high morbidity among the public. In present study, the first group was determined as a control. Group 2 was applied to rats by adding 1% ethylene glycol to drinking water. Group 3 rats were given 50 mg/kg otolith by gavage daily. Group 4 rats were administered by adding ethylene glycol and otolith was given. Group 5 rats were added ethylene glycol for the first 30 days. Then next 15 days, the rats were given only otolith. the Serum CREA and BUN levels and urine calcium, phosphate and pH levels were determined to be damaged by ethylene glycol. Free radicals and oxidative damage caused by ethylene glycol were determined from oxidative/antioxidative parameters. Ethylene glycol has also been shown to be inflammatory. There is no positive effect on oxidative stress. From the levels of TNF-α and IL-1β in renal tissue, SUO has shown the triggering effect of inflammation. All data indicate that otolith is not an agent that can be used in nephropathy in the kidney. It is thought that caution should be exercised regarding its use.

Highlights

Sciaena umbra (Linnaeus 1758), is a sea fish, belongs to the Sciaenidae family
When oxidative/ antioxidative parameters were examined in erythrocytes/plasma and tissue, free radicals generated by ethylene glycol and oxidative damage were determined
There is an inflammatory effect caused by Ethylene Glycol (EG) from tissue and serum cytokine levels

Summary

Introduction

Sciaena umbra (Linnaeus 1758), is a sea fish, belongs to the Sciaenidae family. The three genera of the family Sciaenidae are Argyrosomus, Sciaena and Umbrina and five different species respectively. Sciaena umbra (Linnaeus 1758) generally lives on the eastern Atlantic coast, the Mediterranean Sea, the Black Sea and the Azov Sea. It is a fish species that lives near the shore, on rocky places and at the sea bottom (depth between 5 m-100 m). There are several studies on development, sexual development and diet (Engin & Seyhan 2009). They are generally found in herds of 4-5 to 30 (Mesa et al 2008). They live about 20 years (Artuz 2006, Marini et al 2006)

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