Does saliva contamination interfere or stimulate regenerative processes applying current biomaterials on oral surgical sites?

Abstract

Innovative dental biomaterials have been developed in order to stimulate higher biocompatibility and faster healing times using responsive surfaces for regenerative procedures. However, saliva is one of the fluids to interact with these biomaterials in the first instance. Studies have revealed significant negative effects on the biomaterials' properties, biocompatibility and bacterial colonisation after saliva contact. Nevertheless, the current literature is unclear about the profound effects of saliva on regenerative procedures. The scientific community urges further detailed studies associating innovative biomaterials/saliva/microbiology/immunology in order to clarify clinical outcomes. This paper discusses and provides information about the challenges of research using human saliva, the lack of standardisation in protocols applying saliva, and tentative applications of saliva proteins associated with innovative dental biomaterials.