Abstract
BackgroundIn the last 20 years, rapid-acting insulin analogs have emerged on the market, including aspart and lispro, which may be efficacious in the management of diabetic ketoacidosis (DKA) when administered by non-intravenous (i.v.) routes. Clinical QuestionIn patients with mild-to-moderate DKA without another reason for intensive care unit (ICU) admission, is the administration of a subcutaneous (s.c.) rapid-acting insulin analog a safe and effective alternative to a continuous infusion of i.v. regular insulin, and would such a strategy eliminate the need for ICU admission? Evidence ReviewFive randomized controlled trials were identified and critically appraised. ResultsThe outcomes suggest that there is no difference in the duration of therapy required to resolve DKA with either strategy. ConclusionCurrent evidence supports DKA management with s.c. rapid-acting insulin analogs in a non-ICU setting in carefully selected patients.
Published Version
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