Does Hospitalizing Patients with Tuberculosis Ensure Compliance with Drug Regimens?

Abstract

Bangladesh, the strain has rapidly spread to many parts of the world. The spread of the India strain of V. cholerae 0139 to southern China was confirmed here by both serological and molecular means. This is not unexpected, given the increasing cross-border trading in southwestern China and poor hygienic conditions made worse by the influx of millions of workers from northern China every year. The India and the Bangladesh strains of V. cholerae 0139 were distinguished with use of molecular typing and biotyping methods. The Guangdong strain described herein was identical to the India strain with respect to biotype, serotype, antibiogram, enterotoxin production, and the hybridization pattern of the ct.A cholera toxin gene. Nevertheless, the cholera toxin gene pattern in V. cholerae is known to be an unstable trait. Ribotyping with a broad-spectrum rRNA probe revealed no difference so far in hybridization pattern among all the 0139 strains (unpublished data), despite the presence of different ctxA gene patterns. It is therefore possible that all of the 0139 strains belonged to the same clonal linage, with subsequent divergence in terms of cholera toxin gene arrangement. The presence of two copies of cholera toxin gene in the 0139 strains was also documented in this case. Ou results agree with those of previous investigators who identified tan em repeats of the cholera toxi gene in V. cholerae 0139. This characteristic probably accounts or the huge quantities of toxin produced by this organism that result in infections of the same severity as V. cholerae 01.