Does glycemic regulation affect hypercoagulable states in diabetic patients?

Abstract

Diabetes is a common disorder, and many studies have shown that patients with diabetes mellitus have increased thrombotic complications including arterial and venous thromboses. Poorly controlled diabetes increases the risk of thrombosis. Recent reports have shown that a shortened activated partial thromboplastin time (APTT) and increased fibrinogen levels indicate a procoagulant condition. In this study, we evaluated the differences in global coagulation test values such as APTT, prothrombin time (PT), or fibrinogen levels, between well and poorly controlled diabetes. Three hundred forty-nine patients with type 2 diabetes mellitus were included. APTT, PT, fibrinogen, fasting plasma glucose (FPG), postprandial plasma glucose (PPG), complete blood count (CBC), serum lipids, and HbA1c have been measured. Those with APTT 7.0 %). No significant differences were found between the two groups in terms of shortened APTT (<22 s), PT (<10.5 s), or fibrinogen levels. Although inexpensive and widely available, global coagulation assays such as APTT, PT, and fibrinogen levels did not prove useful for evaluating hypercoagulable states in patients with diabetes.