Abstract
Purpose: To determine if cyst fluid CEA can be used to differentiate between benign and malignant cystic neoplasms of the pancreas. Methods: A retrospective case control study was conducted; all mucinous pancreatic cystic lesions that have been surgically resected at one institution from January 1, 2000, to June 1, 2008, were identified and reviewed. Information on cyst fluid CEA level was retrospectively gathered. Results: A total of 123 mucinous cystic lesions of the pancreas were resected at the Hospital of the University of Pennsylvania within this time frame. Of these, 91 patients underwent endoscopic ultrasound (EUS) evaluation prior to surgical resection. Of these, 30 patients had cyst fluid CEA evaluated. Table 1 describes cyst fluid CEA level by lesion type. There was no significant association identified between CEA level (per 1000 unit increase) and aggressive behavior of the lesion, defined as moderate dysplasia or higher (OR 1.004, 95% CI 0.974-1.035).Table: ResultsConclusion: While cyst CEA level can be used to differentiate between mucinous and non-mucinous cystic lesions of the pancreas, it does not allow the clinician to determine malignancy potential of mucinous cystic lesions of the pancreas.
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