Does an increase in the ratio of cytoplasmic NADPH to NADP + accompanied by a decrease in the ratio of cytoplasmic NADH to NAD + mediate the actions of insulin?

Abstract

This paper proposes that both a decrease in the cytoplasmic ratio of NADH NAD + and an increase in the ratio of NADPH NADP + may account for many biological actions of insulin. Evidence in support of this hypothesis is discussed.