Abstract

Do the Infant Respiratory Distress Syndrome and Presumed Sepsis affect Thyroid Function in Preterm Newborns within the First 10 Days of Life?

Highlights

  • It is well established that, in full-term newborns, levels of Thyroxine (T4) rise in the first 48 hours, rising up to values two to three times higher than those found in adults, before stabilizing and returning to the values measured in cord blood within five to six days [1,2]

  • The odds that Thyroid-Stimulating Hormone (TSH) and free T4 concentrations would be abnormal on the day 3 of life in Preterm Infants (PI) may be associated with Gestational Age (GA) and presumed sepsis, but not on the day 10 of life

  • Free T4 would be abnormal on day 3 and day 10 of life were influenced by GA

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Summary

Introduction

It is well established that, in full-term newborns, levels of Thyroxine (T4) rise in the first 48 hours, rising up to values two to three times higher than those found in adults, before stabilizing and returning to the values measured in cord blood within five to six days [1,2]. It is still controversial whether diseases that occur with greater frequency in preterm infants, such as the Infant Respiratory Distress Syndrome (IRDS, formerly known as hyaline membrane disease) and sepsis, hinder interpretation of thyroid function tests [3,4]. Thyroid function seems to be the predominant mode in which the body defends itself metabolically, through a reduction in energy expenditure [5]. Within this context, we investigated whether preterm infants who develop IRDS and/or sepsis in the first 10 days of life exhibit changes in thyroid function

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