Do Smoking and Drinking Habits and Obesity Affect Prevalence of Colorectal Neoplasia in Patients With Positive Immunochemical Fecal Occult Blood Test?

Abstract

G A A b st ra ct s tertiary center. Prolonged SBTT was defined as >6 hours. Regional and whole gut transit times were analyzed. For pts with slow SBTT, average amplitude (AUC) and frequency of contractions (Ct) 60 minutes before and after gastric emptying (GET) were analyzed and compared to the pressure profile of 66 healthy controls. Results: 77 pts underwent WMC test due to upper GI symptoms and suspected GI dysmotility. Of those, 10 pts (13%) had SB motility disorder with isolated prolonged SBTT, but normal gastric and colon transit times. Mean SBTT was 461 min (360-600), significantly longer than normal (p=0.001). The CTT in this group was not significantly different from healthy subjects. There was a tendency to have longer, although normal, mean GET 239 min (p=0.04), compared to healthy subjects. Pressure data: no significant differences were found between pts with isolated slow SBTT and healthy controls in Ct and AUC. The clinical presentation of the pts with isolated SBTT delay was analyzed. Upper GI symptoms were the most common: upper abdominal pain and discomfort -80%, bloating60%, nausea-50%, early satiation-50%, fullness sensation40%, vomiting30%, weight loss30%, abdominal distention-30%, loss of appetite20%, constipation50%. Two pts had DM. In all pts, extensive GI work up, including GES in 2 pts, was unrevealing prior to the WMC test. Following documenting of slow SBTT, in 50% of pts new treatment was initiated -3 pts were treated with lubiprostone, 2 pts were treated for SIBO. Conclusions: SB transit delay might be the underlining pathophysiology for GI symptoms in a subset of pts. Postprandial symptoms are the most common. Evaluation of SBTT by WMC might be considered for patients with upper GI symptoms resembling gastroparesis, in whom no other abnormality of GI tract was identified. An abnormal SBTT could serve as a target for treatment if found.