Do Platelet Indices Have an Effect On Mortality in Peptic Ulcer Perforation?

Abstract

Abstract: Peptic ulcer disease (PUD) is an ulcerative lesion that extends to the submucosa or muscularis propria in the acid-induced stomach and duodenum. Peptic ulcer perforation (PUP) is the second-most common complication observed in 2%–10% of PUD cases. Material and methods: The records of 70 patients who were operated with a diagnosis of PUP between January 2010 and December 2018 were reviewed retrospectively. The mean platelet volume (MPV), platelet distribution width (PDW), white blood cell (WBC) count, and platelet count in the preoperative blood tests and at mortality were recorded in the patients. The patients were divided into two groups: those who did not develop mortality (Group 1) and those who developed mortality (Group 2). Results: Mortality was seen in 10 (14.2%) patients, of which five each were male and female. All patients who developed mortality did so in the early postoperative period (6th hour and 2nd day). There was a statistically significant difference in MPV and PDW values (p < 0.015 and p < 0.015, respectively). As a result, in our study, we think that preoperative high MPV and PDW values can be used to predict mortality in patients who will be operated for PUP. We anticipate that changes in MPV and PDW may be due to sepsis developed secondary to peritonitis due to perforation.