Abstract
Purpose: Lymphocytic colitis (LC) is a chronic inflammatory disease of the colon. It is not known whether LC is associated with an increased risk for adenomas, thereby necessitating surveillance colonoscopy. The aim of the study was to assess the prevalence of adenomas in patients with LC compared to controls. Methods: From 1994–2004, 354 patients with LC and 309 patients with chronic diarrhea who underwent colonoscopy to exclude microscopic colitis and the biopsies were normal, were identified from our pathology database. Age-specific prevalence of adenomas between the two groups was compared using a logistic regression model. Results: Thirty-fourpatients (9.6%) in the LC group and 31 patients (10.0%) in the control group had adenomas (P = 0.85). There was no difference in the prevalence of adenomas in the LC and control groups (P = 0.56), after adjusting for age. There were no differences in the mean size, mean number, and frequency of advanced adenomas between the 2 groups. In a separate study of screening colonoscopy in 272 patients >50 yrs at average risk from our institution, adenomas were identified in 67 patients (25%), which was significantly higher than that of the LC (31/219, 14.2%) or the control (25/175, 14.3%) groups with age >50 yrs in the current study (P <0.01). Conclusions: Lymphocytic colitis does not increase the risk for adenomas. Routine surveillance colonoscopy is not warranted in patients with LC.Table: Prevalence of Adenomas
Published Version
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