Do Gamma Rays of Cancer Radiotherapy Effect on the Sequence of Collagenase Gene?

Abdelmonsefa Elhadary,Samia.E Ali,Mohammedh Awwad,Omari Ghonemy,Amrm Mousa

doi:10.21474/ijar01/1243

Abstract

31Aug 2016 Do Gamma Rays of Cancer Radiotherapy Effect on the Sequence of Collagenase Gene? Amr M. Mousa , Mohammed H. Awwad , Samia. E. Ali , Abdelmonsef A. Elhadary and Omar I. Ghonemy Department of biological Applications, Nuclear Research Center, Atomic Energy Authority, Egypt. Department of Zoology, Faculty of Science, Benha University, Egypt.

Highlights

Eighty male mice were used for this experiment; it is divided into 8 groups, 10 mice / each; which were Normal, beside three groups of normal mice and three groups of tumor transplanted mice each of them exposed to the following accumulated doses (6, 9 and12 Gy)
It was suggested that metastatic cells have an intrinsic signature pattern, the ‘‘poorprognosis signature’’ that accounts for their metastatic behavior
Recent studies have merged these metastasis theories by showing that in addition to a poor-prognosis signature, the metastatic cells must activate additional genes, which are not activated in the primary tumor (Kang et al, 2003)

Summary

Introduction

Eighty male mice were used for this experiment; it is divided into 8 groups, 10 mice / each; which were Normal, beside three groups of normal mice and three groups of tumor transplanted mice each of them exposed to the following accumulated doses (6, 9 and[12] Gy). MSA showed some nucleotide changes in R1.5Gy group when compared to the normal collagenase IV gene sequence, such; C/G, T/A, G/A, G/C, G/C, G/C, T/G, A/T, G/T,C/G, G/T, A/T, G/A, G/A, G/T, G/T, G/C, G/C, G/C, A/T and G/T at positions; 10, 11, 12, 60, 61, 62, 92, 93, 94, 110, 135, 136, 160, 161, 174, 175, 193, 194, 195, 208 and 209, respectively.

Results

Conclusion