Abstract
Inadequate vitamin D level is associated with various adverse medical outcomes. There is a growing concern that insufficient vitamin D may play a role in the development of psychiatric symptoms. This study aims to answer the question: do children with mental disorders have a higher prevalence of hypovitaminosis D? A retrospective chart review examined 25 hydroxyvitamin D (25(OH)D) levels in youth ages 7 to 17 (n=67) at two Oregon psychiatric residential facilities. Vitamin D deficiency is defined as <20 ng/ml and insufficiency as <30 ng/ml. Diagnoses were organized into six categories. 25(OH)D levels were compared across genders and diagnostic groups using a two-sample t-test and ANOVA, respectively. Statistical differences in prevalence across diagnostic categories were calculated using a Pearson chi-square test. Using the data from Saintonge’s NHANES III study on healthy US children for comparison, 21% of our cohorts were found to be vitamin D deficient and 64% insufficient, in contrast to 14% and 48%, respectively. While our results are not statistically significant, mainly because of small sample size, the overall mean 25(OH)D level in our cohort was insufficient (27.59 ± 9.35 ng/ml), compared to a sufficient mean value of 32.1 ng/ml in the general population. No statistical significant difference was found in the prevalence across diagnostic categories. This study found that children with psychiatric disorders might have a higher prevalence of hypovitaminosis D than the general pediatric population. Although a causal relationship between hypovitaminosis D and psychiatric disorders cannot be derived based on the study design, our study provides initial descriptive data on the prevalence of hypovitaminosis D in children with psychiatric disorders, which has not been previously reported to our knowledge. Prospective studies with a larger sample size and controlled variables would allow more precise analysis of the relationship between hypovitaminosis D and childhood mental disorders.
Highlights
An inadequate vitamin D level is increasingly being linked to diverse disease states
A Swedish study found that patients diagnosed with schizophrenia and autism had the lowest 25-hydroxyvitamin D (25(OH)D) levels among psychiatric diagnoses, and proposed that low 25(OH)D may be a predisposing developmental factor, but may affect mental health in adulthood[3]
As research continues on the impact of vitamin D in medicine, its implication for psychiatric disorders may be clarified
Summary
An inadequate vitamin D level is increasingly being linked to diverse disease states. Beyond its importance in endocrine and bone health, there is a growing concern that vitamin D insufficiency may affect brain function and mental health. Studies have linked hypovitaminosis D to various psychiatric disorders such as depressed mood[1] and schizophrenia[2,3]. A Finnish study found that vitamin D supplementation in infancy reduced the risk of schizophrenia later in life among males[7]. A Swedish study found that patients diagnosed with schizophrenia and autism had the lowest 25-hydroxyvitamin D (25(OH)D) levels among psychiatric diagnoses, and proposed that low 25(OH)D may be a predisposing developmental factor, but may affect mental health in adulthood[3]. Prevention of hypovitaminosis D in early life may be associated with reduced risk of developing certain psychiatric disorders
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
