Abstract
Over the last few years, DNA-surfactant complexes have gained traction as unique and powerful materials for potential applications ranging from optoelectronics to biomedicine because they self-assemble with outstanding flexibility spanning packing modes from ordered lamellar, hexagonal and cubic structures to disordered isotropic phases. These materials consist of a DNA backbone from which the surfactants protrude as non-covalently bound side chains. Their formation is electrostatically driven and they form bulk films, lyotropic as well as thermotropic liquid crystals and hydrogels. This structural versatility and their easy-to-tune properties render them ideal candidates for assembly in bulk films, for example granting directional conductivity along the DNA backbone, for dye dispersion minimizing fluorescence quenching allowing applications in lasing and nonlinear optics or as electron blocking and hole transporting layers, such as in LEDs or photovoltaic cells, owing to their extraordinary dielectric properties. However, they do not only act as host materials but also function as a chromophore itself. They can be employed within electrochromic DNA-surfactant liquid crystal displays exhibiting remarkable absorptivity in the visible range whose volatility can be controlled by the external temperature. Concomitantly, applications in the biological field based on DNA-surfactant bulk films, liquid crystals and hydrogels are rendered possible by their excellent gene and drug delivery capabilities. Beyond the mere exploitation of their material properties, DNA-surfactant complexes proved outstandingly useful for synthetic chemistry purposes when employed as scaffolds for DNA-templated reactions, nucleic acid modifications or polymerizations. These promising examples are by far not exhaustive but foreshadow their potential applications in yet unexplored fields. Here, we will give an insight into the peculiarities and perspectives of each material and are confident to inspire future developments and applications employing this emerging substance class.
Highlights
Over the last few years, deoxyribonucleic acid (DNA)–surfactant complexes have gained traction as unique and powerful materials for potential applications ranging from optoelectronics to biomedicine because they self-assemble with outstanding flexibility spanning packing modes from ordered lamellar, hexagonal and cubic structures to disordered isotropic phases
The investigation of DNA function in a water-free environment expands the use of DNA outside of the conditions traditionally dictated by nature benefiting the many technologies that are incompatible with aqueous systems, such as high- and low-temperature applications.[13]
Amplified spontaneous emission (ASE) and lasing in a two-layer system composed of a DNA–CTMA/Rhodamine 6G layer superimposed on a periodic surface relief grating structure were investigated and compared.[146]
Summary
To the efforts undertaken with fully synthetic polymers. Complexation of DNA and surfactants, for example, leads to spontaneous formation of highly organized assemblies induced by their molecular shape and weak intermolecular interactions, such as van der Waals and dipolar forces.[7,8,9,10] The inherent structural flexibility of these complexes can lead to a variety of scientific and technological pursuits. The investigation of DNA function in a water-free environment expands the use of DNA outside of the conditions traditionally dictated by nature benefiting the many technologies that are incompatible with aqueous systems, such as high- and low-temperature applications.[13] Introducing phase changes by temperature is achieved by employing DNA–surfactant solventfree liquid crystalline materials[14,15] allowing the development of flexible and printable DNA electronic components where water. We outline seminal and recent research in this exciting field introducing DNA and its properties, while focusing on the self-assembly behaviours of DNA–surfactant and DNA–lipid complexes and eventually discussing advantages and disadvantages of these complexes in various applications from biomedicine to bioelectronics
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.