DNA repair mechanisms and their biologic implications in mammalian cells: Report of a NATO advanced research workshop, Fontevraud, France, Oct. 2–7, 1988

Abstract

Repair of Alkylation Damage in DNA.- Structure-Function Relationships in Alkylation Damage and Repair.- The Roles of Beta- and Delta-Elimination in the Repair of AP Sites in DNA.- Imidazole Ring-Opened Purines: Occurence and Repair in Escherichia coli and Mammalian Cells.- Substrate Specificity of the Formamidopyrimidine-DNA Glycosylase of E. coli: Repair of the Imidazole Ring-Opened Form of N-Hydroxy-2-Amino-Fluorene-Guanine Adducts in DNA.- Investigation of Sequence Specificity in DNA Alkylation and Repair Using Oligodeoxynucleotide Substrates.- Towards a Role for Promutagenic Lesions in Carcinogenesis.- Acquisition of Resistance to Alkylating Agents by Expression of Methyltransferase Gene in Repair-Deficient Human Cells.- The Mer Minus Phenotype, Patient Response to Nitrosoureas, and Protooncogene Activation in Human Glioblastomas.- The Molecular Basis of Alkylating Agent Resistance in Mammalian Cells.- Differential Repair of O4-Methylthymine and O6-Methylguanine in Rat and Hamster Liver.- Formation of 1, N6-Ethenodeoxyadenosine and 3, N4-Ethenodeoxycytidine in DNA from Several Organs of Rats Exposed to Vinyl Chloride.- The Role of O6-Alkylguanine in Cell Killing and Sister Chromatid Exchange Induced by Alkylating Agents.- Inducible Responses to DNA Damage.- Inducible Repair in Mammalian Cells Treated with Alkylating Agents.- An Update of the Mammalian UV Response: Gene Regulation and Induction of a Protective Function.- DNA Repair Related Events.- The Transportation of AP Endonuclease from Cytoplasm to Nucleus in Mammalian Cells.- DNA Damage and Oxygen Species.- Mutagenesis.- Molecular Studies of Mutagenesis using Plasmid Vectors in Xeroderma Pigmentosum Cells.- Molecular Analysis of Mutations at the HPRT Locus: UV Mutation Spectra in Normal and UV-Sensitive V79 Chinese Hamster Cells.- Comparison of the Mutational Specificities Exhibited by BPDE in Escherichia coli and CHO Cells.- Deoxyribonucleotide Pools, DNA Repair and Mutagenesis.- Recombination and Mismatch Repair.- Duplex-Duplex Homologous Recombination Catalysed by a Human Nuclear Extract. Involvement in Double-Strand Break Repair.- Proteins from Yeast and Human Cells Specific for Model Holliday Junctions in DNA.- Characterization of a Strand Transferase Activity from Human Cells.- Mismatch Repair in Mammalian Cells: Approaches to the In Vitro Study of DNA Mismatch Correction Reactions.- Mismatch Repair Patterns in Simian Cells Correlate with the Specificity of a Mismatch Binding Protein Isolated from Simian and HeLa Cells.- Chromatin Proteins and Chromatin Structure in DNA Repair.- DNA Excision Repair at the Nucleosome Level of Chromatin.- Modulation of Activity of Human Chromatin-Associated Endonucleases on Damaged DNA by Nucleosome Structure.- Relationship Between DNA Repair and Transcription in Defined DNA Sequences in Mammalian Cells.- Non-Random Distribution of UV-Induced Repair in Higher-Order Chromatin Loops in Human Cells and its Relationship to Preferential Repair of Active Genes.- Electron Microscopic Visualization of Chromatin Structure at Sites of DNA Excision Repair Following Ultraviolet Irradiation of Cultured Human Fibroblasts.- Poly(ADP-Ribosyl)ation Reactions and Modulation of Chromatin Structure.- Variation of Nuclear ADP-Ribosyl Transferase in Rat Liver Carcinogenesis and in Synchronized HeLa Cells.- DNA Repair Processes in Mutant Cells Deficient in Poly(ADP-Ribose) Synthesis.- Repair Defective Cell Types.- Co-Recessive Inheritance: A Model for Diseases Associated with Defective DNA Repair.- Mammalian DNA Ligases and the Molecular Defect in Bloom's Syndrome.- Detection of Unique Antigenic Lesions in the Uracil DNA Glycosylase from Bloom's Syndrome.- DNA Ligase Activity in Human Cells from Normal Donors and from Patients with Bloom's Syndrome and Fanconi's Anemia.- Processing of Photoinduced Cross-Links and Monoadducts in Human Cell DNA: Genetic and Molecular Features.- Parallels Between Nucleotide Excision Repair in Human Cells and E. coli.- Mechanisms of Resistance to Ionising Radiations: Genetic and Molecular Studies on Ataxia-Telangiectasia and Related Radiation-Sensitive Mutants.- Defective DNA Synthesis and/or Repair in Amyotrophic Lateral Sclerosis.- Genetic Analysis in Trichothiodystrophy Repair Deficient Cells Confirms the Occurrence of Xeroderma Pigmentosum Group D Mutation in Unrelated Patients.- Chinese Hamster Cell Lines Defective in DNA Repair.- DNA Repair Genes and Oncogenes in DNA Repair.- Human DNA Repair and Recombination Genes.- Molecular Genetic Dissection of Mammalian Excision Repair.- The Cloning and Characterization of a Candidate Gene for the Correction of the Xeroderma D Defect.- Characterization of Chinese Hamster Ovary Cell Mutants Hypersensitive to DNA Damaging Agents.- Oncogene Activation in Xeroderma Pigmentosum Skin Tumors.- Anticancer Drugs in DNA Repair.- Heterogeneity in the O6-Alkylguanine DNA Alkyl-Transferase (AGT) Activity of Human Peripheral Blood Lymphocytes (PBL's).- Formation and Repair of Adducts that Lead to Cross-Links in DNA Treated with Chloro-Ethylating Agents.- Induction of Futile DNA Repair Processing by Bifunctional Intercalators.- Participants.- Author Index.