Abstract
The DNA repair gene, X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism may be associated with a susceptibility to glioma. The present study aimed to investigate the association between the XRCC3 Thr241Met polymorphism and the potential susceptibility to gliomas. A hospital-based case-control study was conducted, which included a total of 886 patients with glioma and 886 healthy control subjects. Peripheral blood samples were extracted and the polymerase chain reaction-restriction fragment length polymorphism method was performed to analyze the genotypes. The glioma patients had a significantly higher frequency of the XRCC3 241 MetMet genotype [odds ratio (OR) = 1.62; 95% confidence interval (CI): 1.09–2.41; P=0.02] compared with the control subjects. When stratified by the grade of the glioma, the patients with stage IV glioma (according to the World Health Organization classification) had a significantly higher frequency of the XRCC3 241 MetMet genotype (OR=1.61; 95% CI: 1.06–2.44; P=0.03). When stratified by the histology of the glioma, there was no significant difference in the distribution of each genotype. The findings of the present study indicate that the XRCC3 Thr241Met polymorphism is associated with a susceptibility to glioma.
Highlights
Gliomas account for >70% of all types of brain tumor [1]
Previous genome‐wide association studies (GWAS) have reported that single nucleotide polymorphisms (SNPs) are associated with glioma susceptibility [9,10]
A meta‐analysis of nine case‐control studies with 3,146 cases and 4,296 control subjects indicated that the XRCC1 Arg399Gln polymorphism was associated with an increased risk of glioma among Asian individuals and borderline increased risk for glioblastoma among Caucasian individuals, whereas the XRCC1 Arg194Trp/Arg280His polymorphisms may have no affect on the susceptibility of glioma among different ethnicities [24]
Summary
Gliomas account for >70% of all types of brain tumor [1]. The estimated five‐year survival rate is 60 and 74% for biopsy, and watchful waiting and early resection in low‐grade gliomas, respectively [2,3]. Gliomas are an enigmatic and heterogeneous disease, the exact etiology of which remains unclear [2]. Certain factors are found to affect an individual's glioma risk, such as hereditary genetic disorders [4], obesity during adolescence [5], being tall and exposure to high doses of ionizing radiation [5,6,7,8]. Certain genome‐wide association studies (GWAS) have reported that single nucleotide polymorphisms (SNPs) are associated with glioma susceptibility [9,10]. The additional factors that contribute to glioma susceptibility require further investigation
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