Abstract
DNA replication is a complicated affair: Proteins must identify where on DNA to start replicating, unwind the double helix, synthesize a primer, and then elongate the DNA strand from the end of that primer. The activity of these proteins is carefully orchestrated to ensure the DNA gets replicated accurately. Increasingly, biochemical researchers are finding that many of the proteins involved in DNA replication incorporate iron-sulfur clusters, which enzymes commonly use for electron transfer. Experiments now suggest that those clusters serve to send a signal through the DNA double helix being synthesized to promote the handoff of the DNA from one replication protein to another (Science 2017, DOI: 10.1126/science.aag1789). “This study represents a significant step forward in several aspects” of our understanding of the control and coordination of DNA replication, comments Tracey Rouault, head of the Molecular Medicine Branch of the National Institute of Child Health & Human Development and a
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