Abstract
The present work describes the synthesis of a few novel Knoevenagel condensed copper(II) complexes from Schiff bases of thiosemicarbazide derivatives. The synthesized compounds have been characterized by various analytical and spectral techniques. The DFT calculations were carried on these compounds using Gaussian 09 W software which theoretically confirmed the change in UV–Vis electronic transitions after complexation. Interestingly, optimization and DFT calculations corroborated the stability and biological approachability of these copper complexes. Also, pharmacokinetic properties of the synthesized compounds have been computed using SWISS ADME online software which theoretically supports the oral mode of administration of the drug and its lead like activity. Moreover, all the copper complexes have the ability to undergo intercalative binding with CT-DNA, which has been confirmed by UV absorption studies, viscosity measurements, CV studies and molecular docking.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
