Abstract
A trans-chelating ligand based on two 2-ethynyl-pyridine arms attached to neighboring positions of a benzene ring was incorporated into DNA single strands by means of solid phase phosphoramidite synthesis. Hybridization of two matching strands each containing one ligand provides a tetradentate N4 coordination environment for metal cations favoring a square-planar geometry inside the DNA double helix. The binding of Cu(II) cations was investigated and an increase in the DNA melting temperature was observed upon metal binding. The new system raises possibilities to design metal-containing DNA nanoarchitectures with potential for applications in molecular electronics, nanomagnets and catalysis.
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