Abstract
Chromatin is made up of nucleosomes, where each nucleosome core particle consists of ∼147 bp of DNA wrapped around an octamer of histone proteins. A canonical histone octamer contains two H2A-H2B dimers and one H3-H4 tetramer. H2A.Z is a well-conserved histone variant in eukaryotes and is essential for viability in metazoans. It is found at +1 nucleosomes next to transcription start sites, DNA replication origins and sites of DNA damage. H2A.Z is enzymatically deposited by SWR1 through an ATP-dependent reaction known as histone exchange.
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