Abstract
Endogenous and exogenous agents constantly inflict damage to the DNA. As a consequence, DNA lesions may cause mutations and ultimately cancer. Alternatively, DNA damage may trigger cell death or senescence, contributing to aging. To prevent these consequences a complex genome maintenance machinery has arisen, including a set of DNA repair systems. One potent DNA repair pathway is nucleotide excision repair (NER) eliminating helix-distorting lesions. Two NER modes exist. Global genome NER (GG-NER) operates genome-wide and prevents mainly mutations (and thereby cancer).
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