Abstract
The design and study of DNA-binding molecules have been of great interest for many years due to their possible applications as diagnostic agents, genetic probes, or chemotherapeutics. Optical spectroscopy methods showed that the binuclear ruthenium complex B (Figure) intercalates into DNA by threading a coordinated ruthenium ion through the DNA base stack, ending up with one subunit in each groove of DNA and the bridging bidppz ligand sandwiched between the DNA base pairs. We here investigate by NMR spectroscopy the detailed structure of B threaded into a short DNA sequence [d (CGCGAATTCGCG)]2 at 25 0C. To obtain further insights into this unusual binding mode, the structural characterization is supplemented by kinetic and thermodynamic studies.
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