Abstract
In this paper, DNA interaction and cytotoxic/phototoxic properties of bis[4-({8)-[3-(trimethylamino)phenoxy]octyl}oxy)] substituted silicon (IV) phthalocyanine (Compound 1) were examined using a UV-Vis spectrophometer and agarose gel electrophoresis techniques. The results showed that Compound 1 bound to ct-DNA via groove binding mode. In nuclease/photonuclease experiments, Compound 1 had low nuclease activity in the dark, but it showed high photonuclease activity in the presence of light, depending on compound concentration and light dose. In addition, Compound 1 demonstrated remarkable phototoxicity toward human lung cancer (A549) cell line at 50 and 100 µM in the presence of light. The in vitro data of the study revealed the potential of Compound 1 as a PDT agent for the treatment of lung cancer. These data need to be supported by further studies.
Published Version
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