Abstract
This chapter discusses DNA and RNA cleavage by metal complexes. DNA and RNA cleavage, a very active field of research, has been developed in two main and complementary directions within the past decade: oxidative cleavage and hydrolysis. In general, the difference between the two different approaches are (1) the preparation of new chemical tools to study genomic DNA. The recognition sites of most of the restriction enzymes are often limited to palindromic sequences, and it is useful to have artificial nucleases able to cleave DNA at any desired sequence, and (2), the synthesis of compounds that cleave nucleic acids should help in the design of potential therapeutic agents for the treatment of cancer and viral diseases. The challenging development of new, efficient DNA and RNA cleavage agents can require a strong cooperation between chemists, biochemists, and molecular biologists.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.