DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases

Abstract

DNA Cleavage by Enediyne Molecules. Enediynes as Probes of Nucleic Acid Structure I.H. Goldberg, et al. The Intrinsic Flexibility and Drug-Induced Bending of Calicheamicin DNA Targets A. Salzberg, et al. Recent Biophysical and Biological Studies on the Mechanism of Action of Calicheamicin G. Krishnamurthy, et al. Kedarcidin and Maduropeptin, Two Novel Chromoproteins with Potent Antitumor Activities N. Zein. Dynemicin A, a Novel Enediyne DNA Cutter Y. Sugiura, T. Kusakabe. Bleomycin: the Paradigm of DNA Cleavers Based on Metal Complexes. Polynucleotide Cleavage and the Expression of Antitumour Activity by Bleomycin S.M. Hecht. Bleomycin Reaction Pathways: Kinetic Approaches R.M. Burger, K. Drlica. Selected Generation and Cleavage of C4'-Modified Oligonucleotides B. Giese. Site-Specific DNA Cleavage. Site Specific Oxidative Scission of Nucleic Acids and Proteins D.S. Sigman. Sequence Selective DNA Cleavage by PNA-NTA Conjugates J. Lohse, et al. The Synthesis and DNA/RNA Hybridization Properties of DNG, a Putative Antisense Agent with an Attractive Polycationic Guanidinium Backbone R.O. Dempcy, T.C. Bruice. Design of Photoactivatable DNA-Cleaving Amino Acids with High Sequence Selectivity I. Saito, et al. Rational Design of a New Class of DNA Cleaver Based on Prediction of Minor Groove Binding Interactions and NMR Structural Studies A. Wilton, et al. Binary Systems of Oligonucleotide Conjugates for Sequence Specific Energy-Transfer Sensitized Photomodification of Nucleic Acids V.V. Vlassov, et al. Mechanism of Oxidative DNA Cleavage. Targeted Oxidative DNA Cleavage Mediated by Oligonucleotide-Cationic Metalloporphyrin Conjugates J. Bernadou, et al. Pulse Radiolysis and Laser Photolysis Studies on Nucleotide Radicals. The Protonation State of the Radicals S. Steenken. Redox Regulation of the Human Immunodeficiency Virus Type 1 (HIV-1) J. Piette. RNA Cleavage by RNase H. Ribonuclease H: from Enzymes to Antisense Effects of Oligonucleotides J.J. Toulme et al. Hydrolysis of RNA by ribozymes and metal complexes. Structure, Activity and Application of Chemically Modified Hammerhead Ribozymes F. Eckstein. The Hairpin Ribozyme J.A. Grasby. Sequence-Specific Cleavage of RNA Using Lanthanide Complexes Linked to Oligonucleotides R. Haner, et al. Synergism of Two Metal Ions for the Hydrolysis of DNA and RNA M. Komiyama, et al. Texaphyrin-Based Nuclease Analogues. Rationally Designed Approaches to the Catalytic Cleavage of RNA and DNA Targets D. Magda, et al. Ribozyme Mimics for Catalytic Antisense Strategies J.K. Bashkin, et al.