Abstract
In this paper, the results on the fabrication of ferroelectric membranes as vascular patches with modified surfaces are presented. For the modification of a membrane surface contacting blood, DLC coating was deposited using the pulsed vacuum arc deposition technique. The physico-chemical properties and cytotoxicity of the membranes modified under various conditions were studied. It was found that DLC coatings do not affect membrane microstructure, preserving its crystal structure as well as its high strength and elongation. It was revealed that an increase in the capacitor storage voltage results in the rise in sp2- and sp-hybridized carbon concentration, which makes it possible to control the chemical structure and surface energy of the modified surface. The experiments with 3T3L1 fibroblasts showed no toxic effects of the materials extracts.
Highlights
According to the World Health Organization, cardiovascular disease ( atherosclerosis of the carotid artery) remains one of the main causes of mortality in developed and developing countries [1,2]
Autologous veins remain the gold standard of vascular patches, but their deficiency significantly limits the availability of such medical help [5]
Owing to their high strength, non-toxicity, chemical stability, and hemocompatibility, electrospun fibrous polymer membranes made of polyvinylidene fluoride and its copolymers, trifluoroethylene (VDF-TrFE) and tetrafluoroethylene (VDF-TeFE), appear to be promising materials for the development of vascular patches [6]
Summary
According to the World Health Organization, cardiovascular disease ( atherosclerosis (stenosis) of the carotid artery) remains one of the main causes of mortality in developed and developing countries [1,2]. The pulsed vacuum arc deposition method appears to be a promising approach for the fabrication of DLC coatings on the surface of polymer membranes [22,23] This method allows for the generation of carbon plasma with ion energy in the range of 40–90 eV by changing the capacitor storage voltage, does not require accelerating potential to the substrate, provides a high rate of condensate formation (up to 1 × 104 Å/s), and the substrate temperature does not exceed 70 ◦ C [24]. We report the possibility of DLC coating deposition on the surface of ferroelectric polymer membranes by means of pulsed vacuum arc deposition, as well as the physico-chemical properties and biocompatibility of the modified membranes, for the first time
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