DL-Valine assisted fabrication of quercetin loaded CuO nanoleaves through microwave irradiation method: Augmentation in its catalytic and antimicrobial efficiencies

Abstract

The DL-valine stabilized CuONL’s were prepared by a facile greener microwave method and characterized by UV–vis absorption spectroscopy, IR, XRD, TEM and TGA analysis. The morphology of CuO nanomaterial was controlled by varying the microwave irradiation time and using two stabilizers DL-valine and sodium dodecyl sulphate. FESEM and EDX techniques were used for the purity analysis of CuONL’s. The BET surface area and porosity of nanomaterial was investigated by BET analysis. The catalyst exhibited excellent catalytic efficiency for the photocatalytic degradation of toxic dyes malachite green and methyl violet. The percentage degradation of malachite green and methyl violet was found to be 94.4 % and 92.4 % respectively. The catalyst also exhibited enhanced activity for the reduction of aromatic nitro compounds. Anticancer and antimicrobial activities of the CuO NL’s were evaluated after loading them with quercetin. The quercetin loading efficiency confirmed with TGA and was found to be 20.71 %. The time kill experiment showed that quercetin loaded NL’s have stronger antimicrobial potential as compared to pure CuO NL’s. Also, the material was found to be effective against A549, MCF7 and K-562 cancer cell lines.