Abstract
To determine the serotype and genotype of dengue virus (DENV) in Bhutan, we conducted phylogenetic analyses of complete envelope gene sequences. DENV-2 (Cosmopolitan genotype) predominated in 2004, and DENV-3 (genotype III) predominated in 2005–2006; these viruses were imported from India. Primary dengue infections outnumbered secondary infections, suggesting recent emergence.
Highlights
To determine the serotype and genotype of dengue virus (DENV) in Bhutan, we conducted phylogenetic analyses of complete envelope gene sequences
Serologic testing indicated that 28 samples from 2004 were positive for dengue by enzyme immunoassay (EIA); 15 were primary infections, and 13 were secondary infections according to published criteria [7]
Phylogenetic analysis of complete E gene sequences indicated that the 2 DENV-2 isolates sampled in 2004 fell into the Cosmopolitan genotype, which is widely distributed throughout the tropical and subtropical world (Figure 1)
Summary
To determine the serotype and genotype of dengue virus (DENV) in Bhutan, we conducted phylogenetic analyses of complete envelope gene sequences. Fiftytwo serum samples from this outbreak were tested by using dengue enzyme immunoassay (EIA) at the National Institute of Communicable Diseases, New Delhi, India. Since the initial report in 2004, fewer clinical cases were reported from Bhutan in 2005 and 2006; dengue virus 3 (DENV)-3 was the dominant serotype [5].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
