Abstract
Oral melanoma (OM) is an ambiguous aggressive neoplasm of the oral cavity. It occurs predominantly in the palate and maxillary gingiva during third to eighth decade of life. The etiology of this deadly neoplasm is still unknown but aberrations in the c-kit pathway are believed to be an initiating factor in melanoma. The clinical course is usually asymptomatic during initial periods but the patient may develop ulceration and pain later. Microscopically, cluster of atypical melanoma cells originating from basal and suprabasal layer of epithelium invade into connective tissue stroma as sheets and cords. Silent progression of disease poses great challenge for early diagnosis and threat of poor prognosis. The author presents an exceptional case of OM, with special emphasis on its pathogenesis, occurring in a 67-year-old male patient.
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