Diverse Pharmacological Potential of Various Substituted Pyrimidine Derivatives

Abstract

Abstract: In many significant bioactive heterocyclic compounds, the six-membered ring pyrimidines play a major role as bioactive components. There is a lot of room for innovation in the fields of medicinal chemistry and the chemical industries because of the numerous pyrimidine synthesis methods and their varied reactions. The pharmacological effects of pyrimidine derivatives include anticonvulsant, antibacterial, antifungal, antiviral, antitubercular, anticancer, antimicrobial, antihypertensive, antiulcer, anti-inflammatory, antimalarial, antioxidant, analgesic, sedative, anti-depressive, antipyretic properties, etc. The synthetic adaptability of pyrimidine has made it possible to create a wide range of structurally different analogs, including analogs from substitution on the pyrimidine ring at various places, which has aided the design of a wide variety of therapeutic targets. This review's goal is to examine the pharmacological effects of numerous pyrimidine derivatives. This review provides an overview of pyrimidine compounds for biological activities and examines the novel pharmacological molecules containing pyrimidine rings in the future.