Abstract
Definite changes in the mitotic index (MI) of bone marrow cells of Wistar rats were discovered during the 24-h period. The curve showing changes in the number of mitoses of the granulopoietic cells is bimodal in character (maxima at 9 a. m. and 8 p. m.), while that for the erythropoietic cells is unimodal (maximum at 9 a. m.). Correlation is observed between changes in MI and the labeling index (incorporation of thymidine-H3) of individual bone marrow cells. The diurnal fluctuations in proliferative activity of the bone marrow cells are accompanied by corresponding changes in the total number of myelokaryocytes.
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