Abstract
Letters15 August 1996Diuretics and Sudden Cardiac DeathMichael S. Horowitz, MDMichael S. Horowitz, MDMontclair, NJ 07042Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-4-199608150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hoes and associates [1] showed an increased risk for sudden cardiac death in hypertensive patients receiving non-potassium-sparing diuretics compared with a reference group, which primarily received potassium-sparing diuretics. The authors attributed this detrimental effect to the hypokalemia and hypomagnesemia produced by the non-potassium-sparing diuretics.Given the antiarrhythmic effect of the potassium-conserving diuretic amiloride in suppressing ventricular premature contractions and runs of ventricular tachycardia [2], the difference in the rate of sudden cardiac death may be explained by a reduced risk for death from cardiac arrhythmia in the patients receiving potassium-sparing diuretics rather than by an absolute increase ...
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