Abstract
Two undescribed diterpenoids (1–2) and three lignans (3a/3b, 4a), together with sixteen known compounds (4b, 5–9, 10a/10b–14a/14b) were obtained from the stems of Tripterygium wilfordii (T. wilfordii). The structures of these new compounds were elucidated by detailed spectroscopic analyses, and their absolute configurations were estabished by ECD calculations. Some compounds exhibited moderate inhibitory activities against IL-6 production in LPS-stimulated RAW 264.7 macrophages in vitro. Compound 5 showed significant anti-inflammatory activity in vitro (IC50, 0.77 μM) and inhibited macrophage polarization towards a pro-inflammatory phenotype.
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