Abstract
Study of ferrum metabolism was performed in 30 patients with traumatic disease, i.e. fractures of the femur, pelvic bones, ribs accompanied by massive muscular hematomas. It has been detected that in severe bone injury besides extravascular hemolysis the intravascular hemolysis, that affects the ferrum metabolism, takes place. Excess of free ferrum activates free radical oxidation processes and results in reduction of total antioxidant activity that is proved by lability of Fe2+ - induced hemiluminescence indices as well as causes the disturbance of blood rheology that influences the course of traumatic disease. Results of experimental study on 30 male Wistar rats in which the conditions of I stage of traumatic shock were created showed that administration of Desferal contributed to blood viscosity improvement.
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