Biochemical Indices at Assessment of Traumatic Disease Course in Multiple Fractures of Extremity Bones When Treated by Ilizarov Technique

Abstract

Dynamics of concentration of the products of protein, carbohydrate, lipid and mineral metabolism in serum and daily urine was studied in 60 patients with multiple closed fractures of the extremities treated by Ilizarov technique. In the period of early traumatic disease complications alkaline phosphatase activity, calcium and hydroxyproline excretion, intensity of hypoproteinemia, hypocalcemia, hypocholesterinemia and hypotriglyceridemia increased in proportion to injury severity. Maximum changes in metabolic status during the period of early traumatic disease complications were observed in patients been operated on 2 nd - 3 rd days after injury. At early terms of traumatic disease the criteria for evaluation of multiple injury severity were the following: increase in alkaline phosphatase level, marked hypocalcemia and hypercalciuria. Long-term preservation of hypocalcemia and hypercalciuria on the background of blood urea increase at traumatic disease stages confirms the disturbance of osteoreparation and requires medicamental correction.