Abstract
Icterus gravis neonatorum is a descriptive term for a clinical syndrome which may be the expression of a variety of pathologic processes. Aside from the symptomatic examples of known cause the interpretation of postmortem observations in regard to pathogenesis presents a problem in each given case and cannot be applied safely to other cases as long as the etiology of the idiopathic types remains unknown. Especially the evaluation of changes in the parenchyma of the liver offers difficulties, because of considerable differences in the pictures described by various observers. In many reports the presence of hemopoietic foci is given prominence, while alterations in the parenchymal cells are treated casually. Occasionally the liver has been described as normal, but most authors have reported acute and sometimes severe changes in the polygonal cells. Such lesions deserve particular attention in cases in which excessive hemolysis does not account for the icterus or in
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