Abstract
Thorotrast (about 2 ml) has been injected intraspinally and intravenously into adult beagle dogs. Excretion rates of thorium daughters have been measured; distributions of thorium and its daughters in the dogs have been measured at times between injection and sacrifice ranging from I to 550 days. A significant but variable amount (10–60 %) of the thorium escapes from the spinal cord and is picked up by the RES, largely by the liver. The “wash-out” of thorium daughters from thorotrast retained in the CNS was similar to that from thorotrast localised in the RES following i.v. injection-thus kinetic parameters derived from i.v. data can be used in calculating doses produced by intraspinal injection. Histological examination shows that after 100 days there is damage to nerve roots, and after 550 days considerable damage. At this time it is estimated that the dose to the cauda equina from alpha rays is about 1000 rads.
Published Version
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