Abstract
The distribution of the adrenoblocking drug pyrroxan in the blood plasma and organs of albino rats was investigated. Pyrroxan was shown to appear rapidly in the brain, liver, kidneys, and other organs and to accumulate selectively in the hypothalamus. The use of a spectrofluorometric method showed that unchanged pyrroxan molecules disappear from the plasma and organs in the course of 2 h. In studies with pyrroxan-14C, radioactivity was detected in the organs for 24 h, but in the plasma for several days, indicating the formation of metabolites of pyrroxan or its complexes with plasma proteins and with structural elements of the organs. The high effectiveness of pyrroxan in different forms of hypothalamic disturbances accompanied by symptoms of overexcitation of the sympathetic nervous system can be explained by its selective accumulation in the hypothalamus.
Published Version
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