Abstract

Backgroud It has been shown that motilin is a brain-gut peptide that mildly distributes in gastrointestinal track,plasma as well as central nervous system.It involves in regulation of gastrointestinal function and plays important roles on multiple levels.Objective The purpose of this paper to discuss the distribution of motilin in central nervous system and its regulating mechanism on gastrointestinal motility.Content This paper reviews motilin including its biomolecular attribute signal pathway,embryonic developing trend and its distribution and function in central nervous system have beened.Trend Central nervous system distribution of motilin and its acting mechanism on gastrointestinal motility have become new study focus.Especially,further researches are deserved to assess the changes of central and peripheral levels of motilin expression induced by pain and its signal pathway. Key words: Motilin; Central nervous system; Gastrointestinal motility; Pain

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